108477-78-7

Basic information

• Product Name: 1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
• Synonyms: 1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS NO: 108477-78-7
• Molecular Weight: 334.378
• Mol File: 108477-78-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile(108477-78-7)
• EPA Substance Registry System: 1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile(108477-78-7)

Safety Data

• Hazardous Substances Data: 108477-78-7(Hazardous Substances Data)

Upstream product

• 70373-49-8 2-cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide 
• 123-54-6 acetylacetone 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 

Relevant articles and documents

Synthesis and anti-hbv activity of 4-aminoanti- pyrine derivatives

The reactions of 4-aminoantipyrine with acetylacetone, ethyl acetoacetate, morpholine, piperazine, and ethyl cyanoacetate were studied. All structures were determined by 1H NMR and mass spectroscopy techniques.

Synthesis of novel 1-pyrazolylpyridin-2-ones as potential anti-inflammatory and analgesic agents

A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3- carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d] pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.