1084774-98-0Relevant articles and documents
Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents
Li, Jun-Feng,Chen, Song-Jie,Zhao, Yu,Li, Jian-Xin
experimental part, p. 599 - 605 (2009/05/27)
Oleanolic acid, a natural product, possesses an anti-osteoclast formation activity. Targeting at discovery of novel and potent anti-bone resorption agents, 22 glycosides of oleanolic acid derivatives (including d-galactopyranosides, d-glucopyranosides, d-xylopyranoses, d-arabopyranoses and d-glycuronic acids) were synthesized at phase-transfer-catalyzed conditions (K2CO3, Bu4NBr, CH2Cl2-H2O) and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1α, 25-dihydroxy vitamin D3 was evaluated in a co-culture assay system. The structure-activity relationships of these compounds were also discussed.