108478-56-4

Basic information

• Product Name: (3'-METHOXY-BIPHENYL-2-YL)-ACETIC ACID
• Synonyms: (3'-METHOXY-BIPHENYL-2-YL)-ACETIC ACID;2-BIPHENYL-(3'-METHOXY)ACETIC ACID;3'-Methoxy-biphenyl-2-acetic acid
• CAS NO: 108478-56-4
• Molecular Formula: C15H14O3
• Molecular Weight: 242.27
• Mol File: 108478-56-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.7 °C at 760 mmHg
• Flash Point: 162.4 °C
• Appearance: /
• Density: 1.175 g/cm³
• CAS DataBase Reference: (3'-METHOXY-BIPHENYL-2-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (3'-METHOXY-BIPHENYL-2-YL)-ACETIC ACID(108478-56-4)
• EPA Substance Registry System: (3'-METHOXY-BIPHENYL-2-YL)-ACETIC ACID(108478-56-4)

Safety Data

• Hazardous Substances Data: 108478-56-4(Hazardous Substances Data)

Usage

General Description

(3'-Methoxy-biphenyl-2-yl)-acetic acid is a chemical compound with the molecular formula C15H14O3. It is a derivative of biphenyl, a well-known aromatic hydrocarbon. (3'-METHOXY-BIPHENYL-2-YL)-ACETIC ACID is a carboxylic acid, meaning it contains a carboxyl group, and the presence of a methoxy group in its structure gives it unique chemical and physical properties. It is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various pharmaceuticals and agrochemicals. This chemical may also have potential uses in the development of new materials and industrial applications due to its aromatic and functional group properties. Additionally, its structural and functional groups make it a useful compound for investigating the structure-activity relationship in drug discovery and development.

Upstream product

• 109092-63-9 (3'-methoxy-biphenyl-2-yl)-acetic acid ethyl ester 
• 109251-54-9 [2-(3-methoxy-phenyl)-cyclohex-1-enyl]-acetic acid ethyl ester 
• 18698-97-0 ortho-bromophenylacetic acid 
• 10365-98-7 3-methoxyphenylboronic acid 

Relevant articles and documents

SAR Studies on tetrahydroisoquinoline derivatives: The role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein

The development of P-glycoprotein (P-gp) ligands remains of considerable interest, mostly for investigating the proteins structure and transport mechanism. In recent years, many different generations of ligands have been tested for their ability to modulate P-gp activity. The aim of the present work is to perform SAR studies on tetrahydroisoquinoline derivatives in order to design potent and selective P-gp ligands. For this purpose, the effect of bioisosteric replacement and the role of flexibility have been investigated, and four series of tetrahydroisoquinoline ligands have been developed: (a) 2-aryloxazole bioisosteres, (b) elongated analogues, (c) 2H-chromene, and (d) 2-biphenyl derivatives. The results showed that both 2-biphenyl derivative 20b and elongated derivative 6g behaved as strong P-gp substrates. In conclusion, important aspects for developing potent and selective P-gp ligands have been highlighted, providing a solid starting point for further optimization.