108535-56-4Relevant articles and documents
Stereoarrayed CF3-Substituted 1,3-Diols by Dynamic Kinetic Resolution: Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation
Cotman, Andrej Emanuel,Cahard, Dominique,Mohar, Barbara
, p. 5294 - 5298 (2016)
CF3-substituted 1,3-diols were stereoselectively prepared in excellent enantiopurity and high yield from CF3-substituted diketones by using an ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation in formic acid/triethylamine. The intermediate mono-reduced alcohol was also obtained in very high enantiopurity by applying milder reaction conditions. In particular, CF3C(O)-substituted benzofused cyclic ketones underwent either a single or a double dynamic kinetic resolution during their reduction. Doubling up: A double dynamic kinetic resolution is described for the ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation of diketones in formic acid/triethylamine to yield the title compounds, displaying a stereotriad, in excellent stereopurity. The intermediate mono-reduced alcohols were isolated in very high enantiopurity by using milder reaction conditions.
A Microbially Based Approach for the Preparation of Chiral Molecules Possessing the Trifluoromethyl Group
Lin, Jenq Tain,Yamazaki, Takashi,Kitazume, Tomoya
, p. 3211 - 3217 (2007/10/02)
The synthetic approach to both enantiomers and diastereomers with the trifluoromethyl group, involving the stereoselective hydrolysis of the ester group and acyclic stereoselection, is described.The absolute configuration of these trifluoromethylated mole
