108540-72-3Relevant articles and documents
DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS
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Page/Page column 23, (2011/02/18)
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 re
Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands
Brunner, Henri,Hankofer, Peter,Holzinger, Ulrich,Treittinger, Barbara,Schoenenberger, Helmut
, p. 35 - 44 (2007/10/02)
The synthesis of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described.The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse.In the P388 test, 53 of the 55 tested complexes fulfill the minimum activity of 125percent T/C required for a substance to be active.