1085443-95-3

Basic information

• Product Name: 3-((6-bromoquinolin-4-yl)amino)phenol
• Synonyms: 3-((6-bromoquinolin-4-yl)amino)phenol
• CAS NO: 1085443-95-3
• Molecular Weight: 315.169
• Mol File: 1085443-95-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-((6-bromoquinolin-4-yl)amino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((6-bromoquinolin-4-yl)amino)phenol(1085443-95-3)
• EPA Substance Registry System: 3-((6-bromoquinolin-4-yl)amino)phenol(1085443-95-3)

Safety Data

• Hazardous Substances Data: 1085443-95-3(Hazardous Substances Data)

Upstream product

• 65340-70-7 6-bromo-4-chloroquinoline 
• 591-27-5 m-Hydroxyaniline 

Relevant articles and documents

Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors

Water networks within kinase inhibitor design and more widely within drug discovery are generally poorly understood. The successful targeting of these networks prospectively has great promise for all facets of inhibitor design, including potency and selectivity for the target. Herein, we describe the design and testing of a targeted library of 4-anilinoquin(az)olines for use as inhibitors of cyclin G-associated kinase (GAK). GAK cellular target engagement assays, ATP binding-site modelling and extensive water mapping provide a clear route to access potent inhibitors for GAK and beyond.

NOVEL SULPHOXIMINE-SUBSTITUTED QUINAZOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) f