1085528-19-3

Basic information

• Product Name: 2-(methoxycarbonylmethylamino)propionic acid
• CAS NO: 1085528-19-3
• Molecular Weight: 161.158
• Mol File: 1085528-19-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 263.1±19.0 °C(Predicted)
• Density: 1.208±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(methoxycarbonylmethylamino)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(methoxycarbonylmethylamino)propionic acid(1085528-19-3)
• EPA Substance Registry System: 2-(methoxycarbonylmethylamino)propionic acid(1085528-19-3)

Safety Data

• Hazardous Substances Data: 1085528-19-3(Hazardous Substances Data)

Usage

Derived from

Glycine (a natural amino acid)

Physical form

White crystalline powder

Solubility

Soluble in water

Uses

Production of pharmaceuticals and agrochemicals, potential use as a building block for new drugs, potential biomarker for certain medical conditions (e.g. liver disease, neuroblastoma)

Industry applications

Versatile compound with potential applications in various industries.

Upstream product

• 2812-31-9 N,N-dimethyl-L-alanine 
• 79-22-1 methyl chloroformate 
• 3913-67-5 N-methylalanine 

Downstream Products

• 58311-53-8 (S)-3,4-dimethyloxazolidine-2,5-dione 

Relevant articles and documents

Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors

Direct chemical modifications provide a simple and effective means to translate bioactive helical peptides into potential therapeutics targeting intracellular protein-protein interactions. We previously showed that distance-matching bisaryl cross-linkers can reinforce peptide helices containing two cysteines at the i and i+7 positions and confer cell permeability to the cross-linked peptides. Here we report the first crystal structure of a biphenyl-cross-linked Noxa peptide in complex with its target Mcl-1 at 2.0 a resolution. Guided by this structure, we remodeled the surface of this cross-linked peptide through side-chain substitution and N-methylation and obtained a pair of cross-linked peptides with substantially increased helicity, cell permeability, proteolytic stability, and cell-killing activity in Mcl-1-overexpressing U937 cells.

METHOD FOR PREPARING ENANTIOMERICALLY ENRICHED N-CARBOXYANHYDRIDE

This disclosure relates to methods for preparing an enantiomerically enriched N-carboxyanhydride of an amino alpha acid of the formula (IIIa) or (IIIb): from a compound of the formula (IIa) or (IIb), respectively: wherein R1, R2, and R3 are as defined in the disclosure.