108554-34-3 Usage
Description
4-Oxo-piperidine-3-carboxylic acid methyl ester, also known as Methyl 4-Oxopiperidine-3-Carboxylate, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents. It is characterized by its 4-oxo-piperidine core and a carboxylic acid ester group, which contribute to its reactivity and potential applications in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
4-Oxo-piperidine-3-carboxylic acid methyl ester is used as a reactant for the synthesis of potent inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). These inhibitors are valuable in the development of drugs targeting metabolic pathways and have potential applications in the treatment of various diseases, including cancer and inflammatory disorders.
Additionally, 4-Oxo-piperidine-3-carboxylic acid methyl ester is used as a reactant in the preparation of phenanthrene-based tylophorine analogues. These cytotoxic agents have potential applications in cancer therapy, as they can target and kill cancer cells while minimizing damage to healthy cells. The development of such agents is crucial for advancing cancer treatment options and improving patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 108554-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,5,5 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 108554-34:
(8*1)+(7*0)+(6*8)+(5*5)+(4*5)+(3*4)+(2*3)+(1*4)=123
123 % 10 = 3
So 108554-34-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H11NO3/c1-11-7(10)5-4-8-3-2-6(5)9/h5,8H,2-4H2,1H3
108554-34-3Relevant articles and documents
Preparation method of nicotinic acid derivative
-
Paragraph 0060-0061, (2019/12/02)
The invention relates to a preparation method of a nicotinic acid derivative. The method comprises the following steps: with N-benzylpiperidine-4-keto-3-formate as a raw material, carrying out a hydrogenolysis reaction to obtain piperidine-4-keto-3-formate; performing halogenation reaction with a certain amount of a halogenation reagent to obtain 3,5-dihalogenated piperidine-4-one-3-formate or 3,5,5-trihalogenated piperidine-4-one-3-formateperforming one-pot process with different alkaline reagent for removing halogen hydride through elimination, and performing hydrolysis and performing acidification with hydrochloric to generate corresponding nicotinic acid derivatives: 4-hydroxynicotinic acid, 4-aminonicotinic acid, 4-hydroxy-5-chloronicotinic acid, 4-amino-5-chloronicotinic acid and 4-amino-5-bromonicotinic acid. The method is simple and convenient to operate, mild in condition, short in technological process, low in wastewater amount, environmentally friendly and low in cost, and green industrial production of the nicotinic acid derivative is facilitated.
