1087318-96-4

Basic information

• Product Name: C₂₃H₂₇NO₆
• Synonyms: C₂₃H₂₇NO₆
• CAS NO: 1087318-96-4
• Molecular Weight: 413.47
• Mol File: 1087318-96-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇NO₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇NO₆(1087318-96-4)
• EPA Substance Registry System: C₂₃H₂₇NO₆(1087318-96-4)

Safety Data

• Hazardous Substances Data: 1087318-96-4(Hazardous Substances Data)

Upstream product

• 520-12-7 pectolinarigenin 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 

Relevant articles and documents

In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines

The effect of novel pectolinarigenin derivatives bearing a dialkylaminoalkyl substituent at O-7 on cell proliferation was evaluated in vitro in a panel of seven human cancer cell lines including renal adenocarcinoma ACHN, amelanotic melanoma C32, colorectal adenocarcinoma Caco-2, lung large cell carcinoma COR-L23, malignant melanoma A375, lung carcinoma A549 and hepatocellular carcinoma Huh-7D12 cell lines. Pectolinarigenin (2), obtained by hydrolysis of rutinose unit of the pectolinarin (1) isolated from Linaria reflexa, exhibited cytotoxic activity against Caco-2, A549 and A375 cell lines with IC50 values of 5.3-8.2 μM. The most active pectolinarigenin derivative was 3 characterized by a dimethylamino-propoxy group in O-7 with IC50 values of 7.2 and 7.4 μM against COR-L23 and A549 cell lines, respectively. A structure-activity relationship analysis of synthesized compounds was performed. None of the tested compounds affected the proliferation of skin fibroblasts 142BR suggesting a selective activity against tumor cells.