108743-14-2

Basic information

• Product Name: Sodium; (S)-5-(2-bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoate
• CAS NO: 108743-14-2
• Molecular Weight: 582.392
• Mol File: 108743-14-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Sodium; (S)-5-(2-bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium; (S)-5-(2-bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoate(108743-14-2)
• EPA Substance Registry System: Sodium; (S)-5-(2-bromo-acetylamino)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoate(108743-14-2)

Safety Data

• Hazardous Substances Data: 108743-14-2(Hazardous Substances Data)

Upstream product

• 19199-82-7 4-nitrophenyl 2-bromoacetate 
• 80407-73-4 N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine 

Relevant articles and documents

Methotrexate Analogues. 30. Dihydrofolate Reductase Inhibition and in Vitro Tumor Cell Growth Inhibition by Nε-(Haloacetyl)-L-lysine and Nδ-(Haloacetyl)-L-ornithine Analogues and an Acivicin Analogue of Methotrexate

Analogues of methotrexate (MTX) with strong alkylating activity were prepared by replacing the L-glutamate side chain with Nω-haloacetyl derivatives of L-lysine and L-ornithine.Haloacetylation was accomplished in 30-40percent yield by reaction