108752-53-0

Basic information

• Product Name: 5-hydroxymethyl-furan-2-carbaldehyde-p-tolylimine
• Synonyms: 5-hydroxymethyl-furan-2-carbaldehyde-p-tolylimine
• CAS NO: 108752-53-0
• Molecular Weight: 215.252
• Mol File: 108752-53-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hydroxymethyl-furan-2-carbaldehyde-p-tolylimine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxymethyl-furan-2-carbaldehyde-p-tolylimine(108752-53-0)
• EPA Substance Registry System: 5-hydroxymethyl-furan-2-carbaldehyde-p-tolylimine(108752-53-0)

Safety Data

• Hazardous Substances Data: 108752-53-0(Hazardous Substances Data)

Upstream product

• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 106-49-0 p-toluidine 
• 57-48-7 D-Fructose 
• 540-23-8 p-toluidine hydrochloride 

Relevant articles and documents

Reductive Amination of 5-Hydroxymethylfurfural by the Hydrogenation of Intermediate Imines in the Presence of a Pt/Al2O3 Catalyst in a Flow Reactor

Abstract: The catalytic properties of a platinum catalyst supported on γ-alumina in the hydrogenation of imines formed during the condensation of 5-hydroxymethylfurfural (HMF) with primary amines in methanol have been studied. The reaction has been run in a flow reactor at a hydrogen pressure of 5 bar and a temperature of 15–65oC. It has been found that the reductive amination of HMF with n-hexylamine; aniline; ortho-, meta-, and para-toluidines; and aniline derivatives containing F, Cl, Br, and I substituents at the para- or meta-positions leads to the formation of N-substituted 5-hydroxymethyl-2-furfuryl amines with high yields (90–99%). At the same time, the reaction of HMF with aromatic amines exhibiting weak nucleophilic properties (o-chloroaniline, p-aminoacetophenone) provides a target product yield that does not exceed 52%.[Equation not available: see fulltext.]