108761-33-7

Basic information

• Product Name: 6-CHLOROINDOXYL-1,3-DIACETATE
• Synonyms: 1-acetyl-6-chloro-1H-indol-3-yl acetate;(1-acetyl-6-chloroindol-3-yl) acetate;6-Chloro indoxyl-1,3-diacetate≥ 98% (HPLC);6-CHLOROINDOXYL-1,3-DIACETATE;ACETIC ACID 1-ACETYL-6-CHLORO-1H-INDOL-3-YL ESTER;6-CHLOROINDOLYL-1,3-DIACETATE;6-Chloro-3-indolyl 1,3-diacetate
• CAS NO: 108761-33-7
• Molecular Formula: C₁₂H₁₀ClNO₃
• Molecular Weight: 251.67
• Product Categories: substrate
• Mol File: 108761-33-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 111-113 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 376.951 °C at 760 mmHg
• Flash Point: 181.774 °C
• Appearance: /
• Density: 1.337 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Store at -20
• CAS DataBase Reference: 6-CHLOROINDOXYL-1,3-DIACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROINDOXYL-1,3-DIACETATE(108761-33-7)
• EPA Substance Registry System: 6-CHLOROINDOXYL-1,3-DIACETATE(108761-33-7)

Safety Data

• Hazardous Substances Data: 108761-33-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow to yellowish brown powder

InChI:InChI=1/C12H10ClNO3/c1-7(15)14-6-12(17-8(2)16)10-4-3-9(13)5-11(10)14/h3-6H,1-2H3

Upstream product

• 108-24-7 acetic anhydride 
• 914221-22-0 2-(acetyl-carboxymethyl-amino)-4-chloro-benzoic acid 
• 99282-79-8 2-carboxymethylamino-4-chlorobenzoic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 79-11-8 chloroacetic acid 
• 936-08-3 2-bromo-4-chlorobenzoic acid 
• 50-84-0 2,4 dichlorobenzoic acid 

Downstream Products

• 149231-54-9 1-acetyl-6-chloro-indol-3-ol 
• 114305-99-6 6-chloro-1H-indol-3-yl acetate 
• 133950-72-8 Nonanoic acid 6-chloro-1H-indol-3-yl ester 
• 68095-16-9 1-acetyl-6-chloro-1,2-dihydro-3H-indol-3-one 
• 700838-52-4 [2-(1-(2'-bromobenzenesulfonyl)-6-chloro-1H-indol-3-yloxy)ethyl]dimethylamine 
• 1629135-25-6 (S)-5-acetyl-7-chloro-4-phenyl-3,4-dihydropyrano[3,2-b]indol-2(5H)-one 
• 1629135-37-0 (R)-5-acetyl-7-chloro-4-phenyl-3,4-dihydropyrano[3,2-b]indol-2(5H)-one 

Relevant articles and documents

A simple procedure for the preparation of 6-chloro-3-acetoxy-1-acetylindole

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Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands

A series of novel conformationally restricted N1-arylsulfonyl-3-aminoalkoxy indoles were designed and synthesized as 5-HT6 receptor (5-HT6R) ligands. Many of the synthesized compounds have moderate in vitro-binding affinities at 5-HT6R. The lead compound 8b (% inhibition=97.2 at 1 μM) from this series has good pharmacokinetic profile in male Wister rats and is active in animal model of cognition like Morris water maze. The details of chemistry, SAR, pharmacokinetics and pharmacological data constitute the subject matter of this report.

BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS AS PDE5 INHIBITORS

The present invention pertains to Benzyl-substituted tetracyclic heterocyclic compounds, as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these Benzyl-substituted tetracyclic heterocyclic compounds.