108763-41-3Relevant articles and documents
Ring size changes in the development of class I HDAC inhibitors
Cho, Er-Chieh,Liu, Chi-Yuan,Tang, Di-Wei,Lee, Hsueh-Yun
, p. 1387 - 1401 (2021/07/06)
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.
Asymmetric total synthesis of martinelline and martinellic acid
Ikeda, Shuhei,Shibuya, Masatoshi,Iwabuchi, Yoshiharu
, p. 504 - 506 (2007/10/03)
Herein, we describe the first asymmetric total synthesis of (-)-martinelline ((-)-2) and the second total synthesis of (-)-martinellic acid ((-)-1) by employing a tandem Mukaiyama-Mannich reaction/aminal cyclization as the key step. The Royal Society of C
2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
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, (2008/06/13)
2-Phenylbenzimidazoles and 2-phenylindoles of formula I wherein A is N or CH, R1is hydrogen or alkyl which optionally carries an OR11group, R11is hydrogen or alkyl, R2is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH—CO—R23, OR21, R21and R22are each hydrogen or alkyl, R23is hydrogen, alkyl or phenyl, R3is —(CH2)q—NR31R32, q is 0, 1, 2 or 3, R31is hydrogen, alkyl, (CH2)rNR33R34, R32is (CH2)rNR33R34, r is 2, 3, 4, 5 or 6, R33and R34are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, or R33and R34and the nitrogen atom form a 3- to 8-membered ring, R4is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH—CO—R43, OR41, R41and R42are each hydrogen or alkyl, and R43is alkyl or phenyl, are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.