108791-78-2

Basic information

• Product Name: Benzenemethanamine, N-[(2-bromophenyl)methylene]-
• CAS NO: 108791-78-2
• Molecular Formula: C14H12BrN
• Molecular Weight: 274.16
• Mol File: 108791-78-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-[(2-bromophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-[(2-bromophenyl)methylene]-(108791-78-2)
• EPA Substance Registry System: Benzenemethanamine, N-[(2-bromophenyl)methylene]-(108791-78-2)

Safety Data

• Hazardous Substances Data: 108791-78-2(Hazardous Substances Data)

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 100-46-9 benzylamine 
• 18982-54-2 o-bromobenzyl alcohol 

Downstream Products

• 170120-62-4 NiBr(CH₃C₅H₄N)(N(CH₂C₆H₅)CHC₆H₄) 
• 1204705-03-2 (S)-2-(benzylamino)-2-(2-bromophenyl)acetonitrile 
• 1428883-50-4 N-benzyl-N-(1-(2-bromophenyl)-3-phenylprop-2-yn-1-yl)-acrylamide 
• 1428883-51-5 1-benzyl-5-(2-bromophenyl)-4-(1-phenylvinyl)-1,5-dihydro-2H-pyrrol-2-one 
• 1428883-52-6 1-benzyl-6-(2-bromophenyl)-5-methylene-4-phenyl-5,6-dihydropyridin-2(1H)-one 
• 1437799-11-5 N-benzyl-2-(N-benzylacetamido)-2-(2-bromophenyl)acetamide 
• 457057-51-1 PtBr(C₆H₄C₆H₄CHNCH₂C₆H₅)(S(CH₃)2) 
• 1067616-23-2 C₁₅H₁₃BrN₂ 
• 57830-48-5 2-((trifluoromethyl)thio)benzaldehyde 
• 1448617-25-1 [PtBr{2-MeC₆H₃CH=NCH₂(C₆H₅)}SMe₂] 

Relevant articles and documents

Synthesis of diverse lactam carboxamides leading to the discovery of a new transcription-factor inhibitor

(Chemical Equation Presented) Diversity is the key: Skeletal diversity is a useful starting point in the search for compounds that modulate protein-biopolymer interactions. A library of 400 lactam carboxamides has been synthesized in a short synthetic sequence and a new compound that inhibits the interaction of a transcription factor (HOXA13) with its DNA target has been discovered, and inhibition of transcription is demonstrated in cells.

Synthesis of polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a one-pot (Ugi-3CR/aza diels-alder/N-acylation/aromatization/SN2) process. A suitable alternative towards novel Aza-analogues of falipamil

We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an improved cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2): two piperazine-linked pyrrolo[3,4b]pyridin-5-ones in 33 and 34%, and a couple of Falipamil aza-analogues in 30 and 35% overall yields. It is worth highlighting the good substrate scope found, because final products are furnished with alkyl, aryl, and heterocyclic substituents. The use of chain-ring tautomerizable isocyanides (as key reagents for the Ugi-type three component reaction) allowed for a rapid and efficient assembly of the polysubstituted oxindoles, which were used in situ toward the complex products, conferring features like robustness, sustainability, and the one-pot approach to this synthetic methodology.

Ugi four-component reaction of alcohols: Stoichiometric and catalytic oxidation/MCR sequences

A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford α-acetamidoamides in good to excellent yields.