108804-52-0

Basic information

• Product Name: 1-acetyl-2-benzoyloxynaphthalene
• Synonyms: 1-acetyl-2-benzoyloxynaphthalene
• CAS NO: 108804-52-0
• Molecular Weight: 290.318
• Mol File: 108804-52-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-acetyl-2-benzoyloxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-2-benzoyloxynaphthalene(108804-52-0)
• EPA Substance Registry System: 1-acetyl-2-benzoyloxynaphthalene(108804-52-0)

Safety Data

• Hazardous Substances Data: 108804-52-0(Hazardous Substances Data)

Upstream product

• 135-19-3 β-naphthol 
• 574-19-6 1-(2-hydroxy-1-naphthyl)ethan-1-one 
• 100-51-6 benzyl alcohol 
• 65-85-0 benzoic acid 
• 1523-11-1 naphthalen-2-yl acetate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 6051-87-2 3-phenyl-1H-naphtho[2,1-b]pyran-1-one 
• 58483-57-1 1-(2-hydroxynaphthalen-1-yl)-3-phenylpropane-1,3-dione 

Relevant articles and documents

Benzoflavone derivatives as potent antihyperuricemic agents

Two series of benzoflavone derivatives were rationally designed, synthesized and evaluated for their xanthine oxidase (XO) inhibitory potential. Among both series, eight compounds (NF-2, NF-4, NF-9, NF-12, NF-16, NF-25, NF-28, and NF-32) were found to exert significant XO inhibition with IC50 values lower than 10 μM. Enzyme kinetic studies revealed that the most potent benzoflavone derivatives (NF-4 and NF-28) are mixed type inhibitors of the XO enzyme. Molecular modeling studies were also performed to investigate the binding interactions of these molecules (NF-4 and NF-28) with the amino acid residues present in the active site of the enzyme. Docking results confirmed that their favorable binding conformations in the active site of XO can completely block the catalytic activity of the enzyme. Benzoflavone derivatives exhibiting potent XO enzyme inhibition also showed promising results in a hyperuricemic mice model when tested in vivo.

Cu(II)-catalyzed oxidative esterification of 2-carbonyl substituted phenols from the alcohol oxidation level

A copper-catalyzed oxidative esterification of 2-carbonyl substituted phenols from the alcohol oxidation level is described. This protocol represents direct access to a range of 2-carbonylated aryl benzoate derivatives, which are important building blocks in the synthesis of natural and pharmacological compounds.

Reactions of Carbonyl Compounds in Basic Solutions. Part 11. The Baker-Venkataraman Rearrangement

The detailed mechanism of the Baker-Venkataraman rearrangement has been studied.The kinetics of the rearrangement of a series of 2-acetylphenyl 3- or 4-substituted benzoates and acetylnaphthyl benzoates catalysed by a basic 'non-nucleophilic' buffer in dimethyl sulphoxide have been measured.Studies of substituent effects, kinetic isotope effects, and acidity function correlations indicate a pathway involving pre-equilibrium formation of the carbanion, followed by rate-determining intramolecular nucleophilic attack.The methanolysis of the 2-acetylphenyl benzoates catalysed by methoxide in methanolic dimethyl sulphoxide has been similary investigated.In this case the pathway appears to involve neighbouring group participation by the ketonic carbonyl group.