108832-16-2

Basic information

• Product Name: 2,4-dichloro-3-phenylquinolin-7-yl methyl ether
• Synonyms: 2,4-dichloro-3-phenylquinolin-7-yl methyl ether
• CAS NO: 108832-16-2
• Molecular Formula: C₁₆H₁₁Cl₂NO
• Molecular Weight: 304.17064
• Mol File: 108832-16-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 399°Cat760mmHg
• Flash Point: 195.1°C
• Appearance: /
• Density: 1.322g/cm³
• Vapor Pressure: 3.27E-06mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 2,4-dichloro-3-phenylquinolin-7-yl methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-3-phenylquinolin-7-yl methyl ether(108832-16-2)
• EPA Substance Registry System: 2,4-dichloro-3-phenylquinolin-7-yl methyl ether(108832-16-2)

Safety Data

• Hazardous Substances Data: 108832-16-2(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-3-phenylquinolin-7-yl methyl ether is a synthetic chemical compound with the molecular formula C15H9Cl2NO and a molecular weight of 298.14 g/mol. It is a derivative of quinoline and contains two chlorine atoms, a phenyl group, and a methyl ether group. 2,4-dichloro-3-phenylquinolin-7-yl methyl ether is used in the field of medicinal chemistry for its potential therapeutic properties. It has been studied for its various biological activities, including its antiviral and anti-tumor properties. Additionally, it has also been investigated for its potential use as a fluorescent probe in biological imaging and as a precursor in organic synthesis. 2,4-dichloro-3-phenylquinolin-7-yl methyl ether is primarily used as a research chemical and is not commonly found in commercial products.

InChI:InChI=1/C16H11Cl2NO/c1-20-11-7-8-12-13(9-11)19-16(18)14(15(12)17)10-5-3-2-4-6-10/h2-9H,1H3

Upstream product

• 28563-22-6 4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolinone 
• 125878-98-0 4-hydroxy-7-methoxy-1-methyl-3-phenyl-2(1H)-quinolinone 
• 125878-99-1 1-ethyl-4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolone 
• 536-90-3 m-Anisidine 
• 83-13-6 diethyl 2-phenylmalonate 

Downstream Products

• 828300-26-1 4-chloro-2-ethyl-7-methoxy-3-phenyl-quinoline 
• 828300-18-1 2-ethyl-3-phenyl-4-(4-bromophenyloxy)-7-methoxyquinoline 
• 828300-21-6 4-(3-bromo-phenoxy)-2-ethyl-7-methoxy-3-phenyl-quinoline 
• 863711-19-7 4-(4-bromo-phenoxy)-2-ethyl-3-phenyl-quinolin-7-ol 
• 828300-19-2 4-(4-bromo-phenoxy)-7-methoxy-2,3-diphenyl-quinoline 

Relevant articles and documents

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling

Traditional approaches to discovery of selective estrogen receptor modulators (SERMs) have relied on ER binding and cell-based estrogen response element-driven assays to identify compounds that are osteoprotective but nonproliferative in breast and uterin

Regioselective Azidation of 2,4-Dichloroquinolines

Reactions of 2,4-dichloroquinolines (2a-f) with sodium azide in DMF lead either regioselectively to 4-azido-2-chloroquinolines (3a-f) or with excess of sodium azide and catalysts to 5-azido-tetrazoloquinolines (4a-f). 2,4-Dichloroquinolines (2g-i) having electron donating substituents in 3-position react with sodium azide in DMF to a mixture of 4-azido-2-chloroquinolines (3g-i) and 5-chlorotetrazoloquinolines (5g-i).When the reaction of the 2,4-dichloroquinolines (2a-i) with sodium azide is carried out in ethanol with addition of methanesulfonic acid, regioselectively 5-chloro-tetrazoloquinolines (5a-i) are obtained.Structural assignments of 3 and 5 have been carried out by 13C-NMR spectra, IR spectra and degradation reactions of the azido- and tetrazolo group to aminoquinolines (7 and 10) via iminophosphoranes (8 and 9).It could be shown that in 2-azido/tetrazolo-quinolines (4 and 5) the tetrazole ring structure is the dominant species.