108837-17-8

Basic information

• Product Name: 2-Propen-1-one, 3-(2-hydroxy-4-methoxyphenyl)-1-phenyl-
• CAS NO: 108837-17-8
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Mol File: 108837-17-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(2-hydroxy-4-methoxyphenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(2-hydroxy-4-methoxyphenyl)-1-phenyl-(108837-17-8)
• EPA Substance Registry System: 2-Propen-1-one, 3-(2-hydroxy-4-methoxyphenyl)-1-phenyl-(108837-17-8)

Safety Data

• Hazardous Substances Data: 108837-17-8(Hazardous Substances Data)

Upstream product

• 66715-26-2 7-methoxy-2-phenyl-chromenylium; chloride 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 98-86-2 acetophenone 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 64-17-5 ethanol 
• 150-19-6 O-methylresorcine 

Downstream Products

• 1381807-65-3 8-methoxy-2-phenyl-3-tosyl-4,4a-dihydro-3H-chromeno[3,4-c]pyridin-5(10bH)-one 
• 1589534-73-5 C₂₄H₂₀O₄ 
• 1589534-44-0 7-methoxy-1,3-diphenylbenzofuro[2,3-c]pyridine 
• 1429326-74-8 3-methoxy-6-phenyl-6,12-methano-12H-dibenzo[d,g][1,3]dioxocin 
• 109397-89-9 3-(2-methoxy-phenyl)-1-(4-methoxy-phenyl)-propan-1-ol 
• 109089-84-1 3-(2-methoxyphenyl)-1-(4-methoxyphenyl)propan-1-one 
• 101737-15-9 (3-acetoxy-benzofuran-2-yl)-(4-methoxy-phenyl)-ketone 
• 876505-29-2 2-(4-methoxybenzoyl)benzofuran-3-ol 
• 39188-79-9 (E)-1-(4-methoxylphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Highly enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone enabled by cooperative organocatalysts

Herein, we developed an enantioselective addition of aliphatic aldehydes to 2-hydroxychalcone promoted by cooperative organocatalysts, giving access to hybrid flavonoids in excellent enantioselectivities. This reaction took advantage of cycloisomerization of 2-hydroxychalcone to form a transient flavylium under the irradiation of 24 W CFL, which was trapped by the in situ generated chiral enamine intermediate. The synergistic action of chiral phosphoric acid secured the excellent outcome of this reaction by ion-pairing with the transient flavylium.

ZrCl4-catalysed synthesis of new 4-(2-hydroxyphenyl)pyrazolo[3,4-b]pyridine derivatives

In the presence of a catalytic amount of zirconium(IV) chloride, an efficient synthesis of new 4-(2-hydroxyphenyl)pyrazolo[3,4-b]pyridines has been developed by the reaction 2-hydroxychalcones with 3-methyl-1-phenyl-1H-pyrazol-5-amine in refluxing ethanol. All these novel compounds have been characterised by 1H NMR, 13C NMR, HRMS, IR spectra and X-ray crystallographic analysis.

Enantioselective intramolecular formal [2 + 4] annulation of acrylates and α,β-unsaturated imines catalyzed by amino acid derived phosphines

The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described. The catalytic reactions afford N-heterocycles with exceptionally high diastereo- and enantioselectivities. The [2 + 4] products are amenable for further transformations to useful molecules such as chiral piperidines and multicyclic structures.