108964-32-5 Usage
Description
Fura 2-AM is a high affinity, excitation-ratiometric fluorescent indicator used for quantifying intracellular Ca2+ concentration. It is a membrane-permeable analog of Fura 2 with high selectivity for Ca2+ binding. Fura 2-AM is a yellow powder that can be delivered into cells by microinjection or using Influx pinocytic cell-loading reagent. After crossing the membrane, the product is quickly metabolized by cytoplasmic esterases.
Uses
Used in Cellular Physiology Research:
Fura 2-AM is used as a calcium indicator for monitoring intracellular calcium levels in various cell types. This application is crucial for understanding cellular signaling pathways and the role of calcium ions in various physiological processes.
Used in Neuroscience Research:
In neuroscience, Fura 2-AM is used as a tool to study neuronal activity and neurotransmission. By measuring changes in intracellular calcium levels, researchers can gain insights into the functioning of neurons and the mechanisms underlying neurological disorders.
Used in Pharmacological Studies:
Fura 2-AM is employed as a research tool in pharmacology to investigate the effects of drugs on cellular calcium signaling. This helps in understanding the mechanisms of drug action and the development of new therapeutic agents.
Used in Biomedical Research:
In biomedical research, Fura 2-AM is used as a diagnostic tool to study the role of calcium ions in various diseases and conditions. This can aid in the development of targeted therapies and personalized medicine approaches.
Used in Drug Delivery Systems:
Fura 2-AM can be used in the development of drug delivery systems, particularly for calcium-related disorders. By incorporating Fura 2-AM into these systems, researchers can monitor the release of therapeutic agents and their effects on cellular calcium levels, ensuring optimal drug efficacy and safety.
Biological Activity
Fluorescent Ca 2+ indicator. Selective for Ca 2+ over other divalent cations Mg 2+ , Zn 2+ , Fe 2+ and Mn 2+ . Used to determine intracellular Ca 2+ concentration.
Check Digit Verification of cas no
The CAS Registry Mumber 108964-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,9,6 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 108964-32:
(8*1)+(7*0)+(6*8)+(5*9)+(4*6)+(3*4)+(2*3)+(1*2)=145
145 % 10 = 5
So 108964-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C44H47N3O24/c1-25-7-8-32(46(16-38(53)65-20-60-26(2)48)17-39(54)66-21-61-27(3)49)35(13-25)58-11-12-59-42-31-14-36(43-45-15-37(71-43)44(57)69-24-64-30(6)52)70-34(31)10-9-33(42)47(18-40(55)67-22-62-28(4)50)19-41(56)68-23-63-29(5)51/h7-10,13-15H,11-12,16-24H2,1-6H3
