108974-49-8

Basic information

• Product Name: 3-(2-methoxy-phenyl)-2-(4-methoxy-phenyl)-3-oxo-propionitrile
• Synonyms: 3-(2-methoxy-phenyl)-2-(4-methoxy-phenyl)-3-oxo-propionitrile
• CAS NO: 108974-49-8
• Molecular Weight: 281.311
• Mol File: 108974-49-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2-methoxy-phenyl)-2-(4-methoxy-phenyl)-3-oxo-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methoxy-phenyl)-2-(4-methoxy-phenyl)-3-oxo-propionitrile(108974-49-8)
• EPA Substance Registry System: 3-(2-methoxy-phenyl)-2-(4-methoxy-phenyl)-3-oxo-propionitrile(108974-49-8)

Safety Data

• Hazardous Substances Data: 108974-49-8(Hazardous Substances Data)

Upstream product

• 7335-26-4 ethyl 2-methoxybenzoate 
• 104-47-2 p-methoxybenzylnitrile 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Relevant articles and documents

A new anionic cyclization reaction: Condensation of benzoate esters with nitriles to give 3-amino-2-inden-1-ones

A new type of anionic cyclization has been discovered in which the condensation of alkyl benzoates with simple nitriles, induced by an excess of LDA, leads directly to substituted-3-amino-1-ones. The corresponding intermediate β-oxonitriles undergo cyclization to give, in most instances, superior yields of the same compounds. Acid hydrolysis of these indenones leads in high yield to the corresponding biologically active (anticoagulant) indandiones.