109012-83-1

Basic information

• Product Name: Propanedioic acid, [(1R)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester
• CAS NO: 109012-83-1
• Molecular Formula: C20H20O5
• Molecular Weight: 340.376
• Mol File: 109012-83-1.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(1R)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(1R)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester(109012-83-1)
• EPA Substance Registry System: Propanedioic acid, [(1R)-3-oxo-1,3-diphenylpropyl]-, dimethyl ester(109012-83-1)

Safety Data

• Hazardous Substances Data: 109012-83-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 68386-85-6 δ-benzoyl-α-cyano-β-phenylbutyramide 
• 94-41-7 benzalacetophenone 
• 868-26-8 dimethyl 2-bromomalonate 
• 108-59-8 malonic acid dimethyl ester 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 1088-32-0 3-phenyl-4-(1-phenylmethylidene)-5-isoxazolone 
• 98-86-2 acetophenone 
• 109012-87-5 2-[3-(Dimethyl-hydrazono)-1,3-diphenyl-propyl]-malonic acid dimethyl ester 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 1214-54-6 5-benzylidene Meldrum's acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Relevant articles and documents

Enantioselective Michael addition of malonic esters to benzalacetophenone by using chiral phase transfer catalysts derived from proline-mandelic acid/tartaric acid

Abstract: Herein, we have explored the enantioselective Michael addition of various malonate esters to benzalacetophenone by successful utilization of chiral phase transfer catalysts derived from proline, mandelic acid and tartaric acid under mild phase t

In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall

Here we report the synthesis, in vitro antifungal evaluation and SAR study of 41 chalcones and analogues. In addition, all active structures were tested for their capacity of inhibiting Saccharomyces cerevisiae β(1,3)-glucan synthase and chitin synthase,

Enantioselective Michael reaction of malonates and chalcones by phase-transfer catalysis using chiral quaternary ammonium salt

The catalytic enantioselective Michael reaction promoted by quaternary ammonium salt from cinchonidine as a phase-transfer catalyst is described. Treatment of malonate with chalcone derivatives under mild reaction conditions afforded the corresponding Michael adducts in good yields with good to moderate enantiomeric excesses.

Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts

Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured with aliphatic aldehyde-derived enones and substituted malonates. The gram scale-up synthesis of adducts can also be successfully achieved under optimal conditions with both excellent yield and enantioselectivity.

Asymmetric CONJUGATE ADDITION of MALONATE ESTERS to α,β- UNSATURATED N-sulfonyl imines: An expeditious route to chiral δ-aminoesters and piperidones

The asymmetric conjugate addition of malonate esters to α,β-unsaturated N-sulfonyl imines is catalyzed by PyBOX/La(OTf) 3 complexes in the presence of 4A? MS. The reaction gives the corresponding E enamines bearing a stereogenic center at the allylic position with good yields and enantiomeric ratios up to 97:3. This reaction provides a synthetic entry to chiral δ-aminoesters and piperidones. Copyright