109034-30-2Relevant articles and documents
Transition Metal-Free Synthesis of 3-Alkynylpyrrole-2-carboxylates via Michael Addition/Intramolecular Cyclodehydration
Teng, Qing-Hu,Xu, Yan-Li,Liang, Ying,Wang, Heng-Shan,Wang, Ying-Chun,Pan, Ying-Ming
, p. 1897 - 1902 (2016/07/06)
A transition metal-free and efficient method for the synthesis of 3-alkynylpyrrole-2-carboxylates from diynones and glycine esters or 2-aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by-product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process. (Figure presented.) .