109142-53-2

Basic information

• Product Name: 1-ethyl-6,8-difluoro-7-(4-hydroxypiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
• CAS NO: 109142-53-2
• Molecular Formula: C₁₆H₁₈ClF₂N₃O₄
• Molecular Weight: 389.7816
• Mol File: 109142-53-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 581.9°C at 760 mmHg
• Flash Point: 305.7°C
• Vapor Pressure: 2.22E-14mmHg at 25°C
• CAS DataBase Reference: 1-ethyl-6,8-difluoro-7-(4-hydroxypiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-6,8-difluoro-7-(4-hydroxypiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride(109142-53-2)
• EPA Substance Registry System: 1-ethyl-6,8-difluoro-7-(4-hydroxypiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride(109142-53-2)

Safety Data

• Hazardous Substances Data: 109142-53-2(Hazardous Substances Data)

Usage

Chemical class

Quinolone family

Explanation

The compound belongs to the quinolone family of chemical compounds.

Explanation

It is a synthetically produced antibiotic that is derived from the chemical nalidixic acid.

Explanation

The primary use of the compound is to treat a variety of bacterial infections, especially those caused by gram-negative bacteria.

Explanation

The presence of hydrochloride salt in the molecule enhances its solubility in water, which is important for its administration as an oral medication.

Explanation

The compound works by inhibiting the activity of bacterial DNA gyrase, an essential enzyme for the replication and repair of bacterial DNA.

Explanation

By interfering with the bacterial DNA replication and repair process, the compound ultimately leads to the death of the bacteria, effectively treating the infection.

Explanation

Due to its potency and effectiveness, the compound is widely used in the medical field for the treatment of a range of bacterial infections.

Derivation

Synthetic antibiotic derived from nalidixic acid

Common use

Treating bacterial infections

Hydrochloride salt

Increased solubility in water

Mechanism of action

Inhibition of bacterial DNA gyrase

Outcome

Bacterial death and effective treatment of infection

Medical application

Widely used for treating various bacterial infections

Relevant articles and documents

Quinolinecarboxylic acid compounds and antimicrobial agent containing the same

Novel compounds of the formula: STR1 wherein R is ethyl, 2-fluoroethyl or cyclopropyl, and X is hydrogen atom or fluorine atom, and a pharmaceutically acceptable salt thereof, which have excellent antimicrobial activities in vivo and hence are useful as an antimicrobial agent, and an antimicrobial composition containing said compound as an active ingredient, and processes for the preparation of the compounds.