1092304-90-9

Basic information

• Product Name: 5-broMoquinoline-2-carbonitrile
• Synonyms: 5-broMoquinoline-2-carbonitrile
• CAS NO: 1092304-90-9
• Molecular Formula: C10H5BrN2
• Molecular Weight: 233.0641
• EINECS: -0
• Mol File: 1092304-90-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-broMoquinoline-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMoquinoline-2-carbonitrile(1092304-90-9)
• EPA Substance Registry System: 5-broMoquinoline-2-carbonitrile(1092304-90-9)

Safety Data

• Hazardous Substances Data: 1092304-90-9(Hazardous Substances Data)

Usage

General Description

5-bromoquinoline-2-carbonitrile is a chemical compound with the molecular formula C10H5BrN2. It is a yellow solid that is commonly used in organic synthesis as a building block for various pharmaceutical and agrochemical products. It is known for its versatile reactivity and can undergo various chemical reactions, such as Suzuki-Miyaura coupling, Sonogashira coupling, and palladium-catalyzed cross-coupling reactions, to form new carbon-carbon bonds. 5-broMoquinoline-2-carbonitrile has also been studied for potential biological activities, including its use as an antineoplastic agent and as a potent inhibitor of the Hedgehog signaling pathway. Furthermore, 5-bromoquinoline-2-carbonitrile has been investigated as a fluorescent probe for the detection of metal ions, such as zinc and copper, in biological systems.

Upstream product

• 846038-45-7 5-bromoquinoline N-oxide 
• 7677-24-9 trimethylsilyl cyanide 

Relevant articles and documents

Synthesis method of 2-cyanoquinoline derivative

The invention discloses a synthesis method of a 2-cyanoquinoline derivative, and belongs to the technical field of synthesis methods of chinoline and derivatives thereof. The synthesis method includes: adopting a compound represented as in formula (I) and trimethylsilyl cyanide as raw materials, dissolving the raw materials in an organic solvent, catalyzing with H-diethyl phosphite and carbon tetrachloride, and adopting alkali as a deacid reagent to prepare a compound represented as in formula (II). The synthesis method of the 2-cyanoquinoline derivative has the advantages that the adopted catalysts are low in cost and easy to obtain, the raw materials are easy to store, reaction conditions are mild, experimental operations are simple, the obtained 2-cyanoquinoline derivative products are easy to purify, high yield and applicability to industrial production are realized, and a novel synthesis method for preparing the 2-cyanoquinoline derivative is provided.

GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.