1092367-94-6

Basic information

• Product Name: N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide
• Synonyms: N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide
• CAS NO: 1092367-94-6
• Molecular Weight: 536.06
• Mol File: 1092367-94-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide(1092367-94-6)
• EPA Substance Registry System: N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide(1092367-94-6)

Safety Data

• Hazardous Substances Data: 1092367-94-6(Hazardous Substances Data)

Upstream product

• 942922-07-8 2-(4-methylpiperazin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 
• 834888-64-1 N-(4-methoxybenzyl)-2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 

Relevant articles and documents

INHIBITORS OF PROTEIN KINASES

The invention provides inhibitors of protein kinases, such as an Src kinase, enzymes which has been implicated in processes such as cell migration, proliferation, and survival. The inhibitors include 2,5-disubstituted derivatives of thiazole wherein the substituents are as defined. The invention also provides a method of using the inhibitors in treatment of cancer, and a method of preparation of the inhibitors by a palladium-catalyzed coupling reaction.