1092523-03-9

Basic information

• Product Name: 6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline
• Synonyms: 6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline;6-Bromo-3,4-dihydro-1-methylquinolin-2(1H)-one;6-bromo-3,4-dihydro-1-methyl-2(1H)-Quinolinone;6-bromo-1-methyl-3,4-dihydroquinolin-2-one
• CAS NO: 1092523-03-9
• Molecular Formula: C10H10BrNO
• Molecular Weight: 240.0965
• Mol File: 1092523-03-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 429.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.500±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.33±0.20(Predicted)
• CAS DataBase Reference: 6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline(1092523-03-9)
• EPA Substance Registry System: 6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline(1092523-03-9)

Safety Data

• Hazardous Substances Data: 1092523-03-9(Hazardous Substances Data)

Usage

General Description

6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline is a chemical compound with the molecular formula C10H10BrNO. It is a heterocyclic compound that contains a bromine atom and a methyl group. This chemical has potential pharmaceutical applications, with research suggesting it may have anti-inflammatory and anti-cancer properties. It is also used in organic synthesis as a building block for creating more complex molecules. Additionally, it is used in the development of new materials and as a reference standard in analytical chemistry. Overall, 6-Bromo-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline has diverse potential applications in the fields of medicine, chemistry, and materials science.

Upstream product

• 3279-90-1 6-bromo-3,4-dihydro-1H-quinolin-2-one 
• 74-88-4 methyl iodide 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1427587-32-3 1-methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one 
• 1611467-39-0 1-methyl-6-{[3-(trifluoromethyl)phenyl]amino}-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

In vivo active aldosterone synthase inhibitors with improved selectivity: Lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives

Pyridine substituted naphthalenes (e.g., I-III) constitute a class of potent inhibitors of aldosterone synthase (CYP11B2). To overcome the unwanted inhibition of the hepatic enzyme CYP1A2, we aimed at reducing the number of aromatic carbons of these molecules because aromaticity has previously been identified to correlate positively with CYP1A2 inhibition. As hypothesized, inhibitors with a tetrahydronaphthalene type molecular scaffold (1-11) exhibit a decreased CYP1A2 inhibition. However, tetralone 9 turned out to be cytotoxic to the human cell line U-937 at higher concentrations. Consequent structural optimization culminated in the discovery of heteroaryl substituted 3,4-dihydro-1H-quinolin-2-ones (12-26), with 12, a bioisostere of 9, being nontoxic up to 200 μM. The investigated molecules are highly selective toward both CYP1A2 and a wide range of other cytochrome P450 enzymes and show a good pharmacokinetic profile in vivo (e.g., 12 with a peroral bioavailability of 71%). Furthermore, isoquinoline derivative 21 proved to significantly reduce plasma aldosterone levels of ACTH stimulated rats.

PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R15, R16, R17 and n are as described herein, compositions including the compounds and methods of using the compounds.