1092654-41-5Relevant articles and documents
Enantio- and diastereoselective Betti/aza-michael sequence: Single operated preparation of chiral 1,3-disubstituted isoindolines
Takizawa, Shinobu,Sako, Makoto,Abozeid, Mohamed Ahmed,Kishi, Kenta,Wathsala,Hirata, Shuichi,Murai, Kenichi,Fujioka, Hiromichi,Sasai, Hiroaki
, p. 5426 - 5429 (2017)
The first enantio- and diastereoselective Betti/intramolecular aza-Michael sequence carried out using a C3-symmetric chiral trisimidazoline organocatalyst is reported. The reaction of phenols and N-tosylimines bearing a Michael acceptor moiety afforded densely functionalized 1,3-disub-stituted isoindolines bearing two stereogenic centers as single diastereomers in high yields (=93%) and excellent enantiose-lectivities (=99.9%).