1092799-92-2

Basic information

• Product Name: (S)-3-(2'-ethylphenoxy)-propane-1,2-diol
• Synonyms: (S)-3-(2'-ethylphenoxy)-propane-1,2-diol
• CAS NO: 1092799-92-2
• Molecular Weight: 196.246
• Mol File: 1092799-92-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-3-(2'-ethylphenoxy)-propane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(2'-ethylphenoxy)-propane-1,2-diol(1092799-92-2)
• EPA Substance Registry System: (S)-3-(2'-ethylphenoxy)-propane-1,2-diol(1092799-92-2)

Safety Data

• Hazardous Substances Data: 1092799-92-2(Hazardous Substances Data)

Upstream product

• 90-00-6 o-Hydroxyethylbenzene 
• 7149-82-8 rac-3-(2-ethylphenoxy)propane-1,2-diol 
• 60827-45-4 (S)-3-chloropropan-1,2-diol 
• 15620-78-7 (R,S)-1-(2′-ethylphenoxy)-2,3-epoxy-propane 

Downstream Products

• 174689-39-5 3-(2-ethylphenoxy)-1[(1R)-1,2,3,4-tetrahydronaphth-1-ylamino]-(2S)-2-propanol hydrogen oxalate 
• 174689-39-5 (S)-1-(2-Ethyl-phenoxy)-3-[(S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)amino]-propan-2-ol; compound with oxalic acid 
• 1430052-95-1 1-(2′-ethylphenoxy)-2,3-epoxy-propane 

Relevant articles and documents

Synthesis of all of the stereoisomers of β3-adrenoceptor antagonist SR 59230 based on the spontaneous resolution of 3-(2-ethylphenoxy)propane-1,2-diol

Racemic 3-(2-ethylphenoxy)propane-1,2-diol 2 has been effectively resolved into (S)- and (R)-enantiomers by a preferential crystallization procedure. Non-racemic diols 2, obtained via a Mitsunobu reaction, have been converted into the non-racemic 1,2-epox

A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors

Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates. Hot pockets: Microtuning of the enzyme active pocket gives a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots, and enhanced activity toward bulky substrates was found.