1092843-92-9

Basic information

• Product Name: (E)-1-phenyl-3-(1H-pyrido[3,2-g][1,4]benzothiazine-5,10-dione-3,4-dihydro-1,1-dioxide)prop-2-en-1-one
• CAS NO: 1092843-92-9
• Molecular Weight: 394.408
• Mol File: 1092843-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-phenyl-3-(1H-pyrido[3,2-g][1,4]benzothiazine-5,10-dione-3,4-dihydro-1,1-dioxide)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-phenyl-3-(1H-pyrido[3,2-g][1,4]benzothiazine-5,10-dione-3,4-dihydro-1,1-dioxide)prop-2-en-1-one(1092843-92-9)
• EPA Substance Registry System: (E)-1-phenyl-3-(1H-pyrido[3,2-g][1,4]benzothiazine-5,10-dione-3,4-dihydro-1,1-dioxide)prop-2-en-1-one(1092843-92-9)

Safety Data

• Hazardous Substances Data: 1092843-92-9(Hazardous Substances Data)

Upstream product

• 880137-65-5 (E)-3-(5,8-dihydro-5,8-dioxoquinolin-2-yl)-1-phenyl-prop-2-en-1-one 
• 300-84-5 hypotaurine 

Relevant articles and documents

Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: Inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis

Sixteen new thiazine-quinoline-quinones have been synthesised, plus one bicyclic analogue. These compounds inhibited neutrophil superoxide production in vitro with IC50s as low 60 nM. Compounds with high in vitro anti-inflammatory activity were also tested in a mouse model of acute inflammation. The most active compounds inhibited both neutrophil infiltration and superoxide production at doses 2.5 μmol/kg, highlighting their potential for development as novel NSAIDs.