109305-79-5

Basic information

• Product Name: leuconolam methyl ether
• CAS NO: 109305-79-5
• Molecular Weight: 340.422
• Mol File: 109305-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: leuconolam methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: leuconolam methyl ether(109305-79-5)
• EPA Substance Registry System: leuconolam methyl ether(109305-79-5)

Safety Data

• Hazardous Substances Data: 109305-79-5(Hazardous Substances Data)

Upstream product

• 128529-80-6 6β,7β-dibromodiazaspiroleuconolam 
• 67-56-1 methanol 
• 93710-27-1 (?)-leuconolam 

Relevant articles and documents

Transformations of the 2,7- Seco Aspidosperma alkaloid leuconolam, structure revision of epi -leuconolam, and partial syntheses of leuconoxine and leuconodines A and F

Several transformations of the seco Aspidosperma alkaloid leuconolam were carried out. The based-induced reaction resulted in cyclization to yield two epimers, the major product corresponding to the optical antipode of a (+)-meloscine derivative. The structures and relative configuration of the products were confirmed by X-ray diffraction analysis. Reaction of leuconolam and epi-leuconolam with various acids, molecular bromine, and hydrogen gave results that indicated that the structure of the alkaloid, previously assigned as epi-leuconolam, was incorrect. This was confirmed by an X-ray diffraction analysis, which revealed that epi-leuconolam is in fact 6,7-dehydroleuconoxine. Short partial syntheses of the diazaspiro indole alkaloid leuconoxine and the new leuconoxine-type alkaloids leuconodines A and F were carried out.