109318-64-1Relevant articles and documents
Design and synthesis of novel camptothecin/5-fluorouracil conjugates as cytotoxic agents
Liu, Ying-Qian,Dai, Wei,Yang, Liu,Li, Hong-Yu
, p. 1817 - 1826 (2011)
In an effort to overcome several limitations associated with the synthesis of camptothecin (CPT), seven conjugates (10a-10g) composed of CPT and a 5-fluorouracil derivative joined by suitable dipeptide linkages were synthesised, and their cytotoxic activi
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7
Huang, Wen-Ting,Liu, Jie,Liu, Jian-Fei,Hui, Ling,Ding, Yi-Lan,Chen, Shi-Wu
, p. 48 - 54 (2012/04/10)
In order to generate compounds with superior antitumor activity and reduced toxicity, a series of conjugates of deoxypodophyllotoxin and 5-FU were synthesized by coupling 4′-demethyl-4-dexoypodophyllotoxin with N-(5-fluorouracil-N1-ly acetic)-
