1093211-85-8

Basic information

• Product Name: 1-[(2,2-Difluoro-1,3-benzodioxol-5-yl)-Methyl]piperazine
• Synonyms: 1-[(2,2-Difluoro-1,3-benzodioxol-5-yl)-Methyl]piperazine
• CAS NO: 1093211-85-8
• Molecular Formula: C12H14F2N2O2
• Molecular Weight: 256.2485664
• Mol File: 1093211-85-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(2,2-Difluoro-1,3-benzodioxol-5-yl)-Methyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2,2-Difluoro-1,3-benzodioxol-5-yl)-Methyl]piperazine(1093211-85-8)
• EPA Substance Registry System: 1-[(2,2-Difluoro-1,3-benzodioxol-5-yl)-Methyl]piperazine(1093211-85-8)

Safety Data

• Hazardous Substances Data: 1093211-85-8(Hazardous Substances Data)

Usage

Chemical structure

Piperazine derivative containing a benzodioxol group and two fluorine atoms

Pharmaceutical properties

Potential pharmaceutical properties

Usage

Often used in the development of new drugs

Industry

Promising candidate for further research and development in the pharmaceutical industry

Medical applications

Potential applications in the treatment of various medical conditions (further studies needed)

Therapeutic effects

Specific therapeutic effects and potential uses yet to be determined through further research

Chemical class

Piperazine derivative

Functional groups

Benzodioxol group, fluorine atoms

Structural features

1-[(2,2-Difluoro-1,3-benzodioxol-5-yl)-Methyl] substitution on the piperazine core

Upstream product

• 110-85-0 piperazine 
• 656-42-8 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde 

Downstream Products

• 1346528-50-4 JNJ-42165279 

Relevant articles and documents

Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channel

Reductive amination by continuous-flow hydrogenation: Direct and scalable synthesis of a benzylpiperazine

A benzylpiperazine was prepared directly from the corresponding benzaldehyde and piperazine on a continuous-flow hydrogenation apparatus. The synthesis was protecting group free, safe, and environmentally friendly. Large-scale synthesis under flow hydrogenation conditions was also demonstrated. Georg Thieme Verlag Stuttgart · New York.

HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditi