1093252-48-2Relevant articles and documents
Synthesis and activity against HBV of novel tetra-seconucleoside analogues of dyphlline having the acyclic chains of ACV and HBG
Ashry, El Sayed H. El,Awad, Laila F.,Rashed, Nagwa,AbdelRahman, Adel,Rasheed, Hana A.
, p. 309 - 317 (2008)
Selective alkylation of dyphylline (1) with (2-acetoxyethoxy)methyl bromide (2a) or 4-acetoxybutyl bromide (2b) afforded 3′-O-[(acetoxyethoxy)methyl] dyphylline (3a) and 3′-O-(4-acetoxybutyl)-dyphylline (3b), respectively. A trans esterification process rather than alkylation of the dihydroxy-propyl side chain in 1 had taken place during the reaction with 2-p-toluoyloxy)ethyl chloride (5) to afford the respective 3′-toluoyloxy derivative 7 and not the anticipated 3′-O-[(p-toluoyloxy)ethyl]-dyphylline (6). Deacylation of 3a,b and 7 afforded 4a,b and 1, respectively. Viral screening of selected compounds against HBV has been investigated. Copyright Taylor & Francis Group, LLC.
