1093252-79-9Relevant articles and documents
A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties
Choong, Ingrid C.,Serafimova, Iana,Fan, Junfa,Stockett, David,Chan, Erica,Cheeti, Sravanthi,Lu, Yafan,Fahr, Bruce,Pham, Phuongly,Arkin, Michelle R.,Walker, Duncan H.,Hoch, Ute
body text, p. 5763 - 5765 (2009/08/15)
The identification of a selective CDK2, 7, 9 inhibitor 4 with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.