109337-81-7Relevant articles and documents
A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates
Varun, Begur Vasanthkumar,Prabhu, Kandikere Ramaiah
, p. 3079 - 3087 (2013/04/24)
A novel, user-friendly, and convenient method for the synthesis of trisubstituted thioureas of arylamines is presented, for the first time, using in situ generated dithiocarbamates of secondary amines. This strategy provides an excellent opportunity to access thioureas containing primary aryl amines. A non-isothiocyanate route to obtain thioureas is the advantage of this strategy, which may provide a useful route to synthesize a variety of biologically active derivatives of thioureas.
Arylthioureas with bromine or its equivalents gives no 'Hugerschoff' reaction product
Yella, Ramesh,Murru, Siva,Ali, Abdur Rezzak,Patel, Bhisma K.
experimental part, p. 3389 - 3393 (2010/08/22)
The in situ generated aryl-alkyl unsymmetrical thiourea obtained by the reaction of an aryl isothiocyanate with an aliphatic secondary amine on treatment with bromine or its equivalent gave exclusively a product having a thioamido guanidino moiety and not the expected Hugerschoff product 2-aminobenzothiazole. A plausible reaction mechanism has been proposed for this unprecedented transformation and the scope has been extended to various substrates. The Royal Society of Chemistry 2010.