109384-39-6

Basic information

• Product Name: N-(o-chlorophenyl)formohydroxamic acid
• Synonyms: N-(o-chlorophenyl)formohydroxamic acid
• CAS NO: 109384-39-6
• Molecular Weight: 171.583
• Mol File: 109384-39-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(o-chlorophenyl)formohydroxamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(o-chlorophenyl)formohydroxamic acid(109384-39-6)
• EPA Substance Registry System: N-(o-chlorophenyl)formohydroxamic acid(109384-39-6)

Safety Data

• Hazardous Substances Data: 109384-39-6(Hazardous Substances Data)

Upstream product

• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 2258-42-6 formyl acetic anhydride 
• 932-33-2 o-Chloronitrosobenzene 
• 298-12-4 Glyoxilic acid 
• 64-18-6 formic acid 

Downstream Products

• 4205-90-7 Clonidin 
• 21709-18-2 N-(2,6-dichlorophenyl)-1,1-dichloromethanimine 

Relevant articles and documents

A Novel Synthesis of Clonidine, an Anti-Hypertensive Drug from o-Chloronitrobenzene

An elegant, cost-effective synthesis of clonidine (4) is reported from readily available starting materials. o-Chlorophenylhydroxylamine (2), obtained from o-chloronitrobenzene, is formylated to N-(2-chlorophenyl)-N-hydroxyformamide (3).In a one-pot procedure, 3 is converted to clonidine by chlorination with thionyl chloride and then with thionyl chloride/sulfuryl chloride, followed by condensation with ethylenediamine.

A facile synthesis of N-aryl-N-hydroxyformamides from N-arylhydroxylamines

Several N-arylhydroxylamines (2) have been formylated for the first time with acetic formic anhydride to yield N-hydroxyformanilides (3) in better yields than hitherto reported.