109386-25-6Relevant articles and documents
Antiparasitic Agents: Part 5 - Synthesis of 4-(Substituted-aryl)amino-7-chloroquinolines as Potential Antimalarial Agents
Chauhan, P. M. S.,Sharma, Satyavan,Bhakuni, D. S.
, p. 1142 - 1145 (2007/10/02)
A series of 4-(4- and 3-substituted-aryl)amino-7-chloroquinolines (11-15, 17, 18, 28) and substituted diphenyl sulphones (8-10, 19-27) have been synthesized and tested for their antiparasitic activity against Plasmodium berghei in mice, Litomosoides carinii in cotton rats and Hymenolepis nana in mice.Of the compounds tested, 11 shows 100percent activity against P. berghei at a dose of 10 mg/kg x 5 days in mice while 23 is effective in eliminating 100percent of the H. nana worms from mice at a single oral dose of 250 mg/kg.