109389-25-5 Usage
Molecular Structure
The compound consists of a pyrimidinone ring with a 2-deoxy-b-D-erythro-pentofuranosyl-5-methyl-4-(1H-1,2,4-triazol-1-yl) substituent.
Complexity
The structure of the compound is complex, which contributes to its unique properties and potential applications.
Building Block
The compound is an important building block in the synthesis of nucleoside analogs.
Applications
The compound has potential applications in pharmaceuticals and biotechnology, particularly in the production of antiviral and anticancer drugs.
Inhibitory Activity
The compound is an important intermediate in the production of drugs due to its ability to inhibit viral and cellular DNA and RNA synthesis.
Antifungal and Antimicrobial Properties
The compound has been studied for its potential antifungal and antimicrobial properties.
Check Digit Verification of cas no
The CAS Registry Mumber 109389-25-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,8 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 109389-25:
(8*1)+(7*0)+(6*9)+(5*3)+(4*8)+(3*9)+(2*2)+(1*5)=145
145 % 10 = 5
So 109389-25-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H15N5O4/c1-7-3-16(10-2-8(19)9(4-18)21-10)12(20)15-11(7)17-6-13-5-14-17/h3,5-6,8-10,18-19H,2,4H2,1H3/t8-,9+,10+/m0/s1
109389-25-5Relevant articles and documents
Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation
Ghanty, Uday,Kohli, Rahul M.,Wang, Tong
supporting information, p. 11312 - 11315 (2020/05/16)
TET family enzymes are known for oxidation of the 5-methyl substituent on 5-methylcytosine (5mC) in DNA. 5mC oxidation generates the stable base 5-hydroxymethylcytosine (5hmC), starting an indirect, multi-step process that ends with reversion of 5mC to un
Convenient intermediates for the preparation of C-4 modified derivatives of pyrimidine nucleosides
Miah, Anwar,Reese, Colin B.,Song, Quanlai
, p. 53 - 65 (2007/10/03)
4-(4-Nitrophenoxy)-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one 15, 5- methyl-4-(1,2,4-triazol-1-yl)-1-(β-D-2-deoxyribofuranosyl)pyrimidin-2(1H)- one 7a and 4-(4-nitrophenoxy)-1-(βD-2-deoxyribofuranosyl)pyrimidin-2(1H)- one 17a, respectively, have been prepared and are recommended as reactive intermediates for the preparation of derivatives of uridine, thymidine and 2'-deoxyuridine which are modified at C-4.