109417-60-9Relevant articles and documents
FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF
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Paragraph 0157-0158, (2018/08/12)
Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.
Identification of a new biaryl scaffold generating potent renin inhibitors
Lacombe, Patrick,Aspiotis, Renée,Bayly, Christopher,Chen, Austin,Dubé, Daniel,Fortin, Réjean,Gallant, Michel,Juteau, Hélne,Liu, Suzanna,McKay, Dan,Roy, Patrick,Wu, Tom
scheme or table, p. 5822 - 5826 (2010/12/19)
The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring such as
Chiral Induction in the Methylation of N-Ethoxycarbonylmethyl Sulfoximines
Hambley, Trevor W.,Raguse, Burkhard,Ridley, Damon D.
, p. 1833 - 1842 (2007/10/02)
Chiral inductions in the C-methylations of four optically active N-ethoxycarbonylmethyl-S-p-tolylsulfoximines were explored by using the reagents lithium diisopropylamide (in tetrahydrofuran at -78 deg) then methyl iodide.When the fourth substituent at su
