1094467-32-9

Basic information

• Product Name: 2-bromo-N-cyclopropyl-5-fluoro-N-methylbenzamide
• CAS NO: 1094467-32-9
• Molecular Weight: 272.117
• Mol File: 1094467-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-cyclopropyl-5-fluoro-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-cyclopropyl-5-fluoro-N-methylbenzamide(1094467-32-9)
• EPA Substance Registry System: 2-bromo-N-cyclopropyl-5-fluoro-N-methylbenzamide(1094467-32-9)

Safety Data

• Hazardous Substances Data: 1094467-32-9(Hazardous Substances Data)

Upstream product

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 111771-13-2 2-bromo-4-fluorobenzoyl chloride 

Relevant articles and documents

Palladium-catalyzed ring-opening of cyclopropyl benzamides: Synthesis of benzo[c]azepine-1-ones via C(sp3)-H functionalization

A variety of difficult to obtain benzo[c]azepine-1-ones are synthesized via a novel palladium-catalyzed, silver-promoted intramolecular cyclization of cyclopropyl benzamides. This biologically important class of molecules is prepared in an efficient and high-yielding manner from easily accessible starting materials. Both aryl bromides and iodides are effective substrates for the transformation. Mechanistic studies indicate that the reaction proceeds through a cyclopropyl C(sp3)-H cleavage step, followed by ring-opening, deprotonation, and reductive elimination.