109466-87-7

Basic information

• Product Name: 2-NITRO-4-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 2-Nitro-4-(trifluoromethyl)benzaldehyde 97%;4-Formyl-3-nitrobenzotrifluoride, 2-Formyl-5-(trifluoromethyl)nitrobenzene, 2-Nitro-alpha,alpha,alpha-trifluoro-p-tolualdehyde
• CAS NO: 109466-87-7
• Molecular Formula: C₈H₄F₃NO₃
• Molecular Weight: 219.12
• Mol File: 109466-87-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 41-45°C
• Boiling Point: 273.8°C at 760 mmHg
• Flash Point: 119.4°C
• Appearance: /
• Density: 1.496g/cm³
• Vapor Pressure: 0.0056mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-NITRO-4-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-4-(TRIFLUOROMETHYL)BENZALDEHYDE(109466-87-7)
• EPA Substance Registry System: 2-NITRO-4-(TRIFLUOROMETHYL)BENZALDEHYDE(109466-87-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 109466-87-7(Hazardous Substances Data)

Usage

General Description

2-Nitro-4-(Trifluoromethyl)benzaldehyde is a chemical compound often used in chemical research and production due to its unique properties. Its IUPAC name is 2-nitro-4-(trifluoromethyl)benzenecarbaldehyde. The compound is an aromatic aldehyde, which contain a carbon-oxygen double bond. Its structure consists of a benzene ring with a nitro group (NO2) and a trifluoromethyl group (CF3) attached to the 2 and 4 positions, respectively, and also an aldehyde group (CHO) attached to the benzene ring. The substance is typically a bright yellow solid in its stable form. Like other aromatic aldehydes, it is a versatile precursor to a wide array of products, including pharmaceuticals, agrochemicals, and dyestuff.

InChI:InChI=1/C8H4F3NO3/c9-8(10,11)6-2-1-5(4-13)7(3-6)12(14)15/h1-4H

Upstream product

• 109466-86-6 4-(trifluoromethyl)-2-nitrobenzaldehyde oxime 
• 778-94-9 2-nitro-4-trifluoromethyl-benzonitrile 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 81108-81-8 2-nitro-4-trifluoromethyl-benzoyl chloride 
• 1012051-66-9 (E)-4-trifluoromethylbenzaldehyde O-methyloxime 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 125903-75-5 4-trifluoromethylbenzaldehyde O-methyloxime 

Downstream Products

• 109466-88-8 2-amino-4-(trifluoromethyl)benzaldehyde 
• 441786-99-8 diethyl 2-nitro-4-(trifluoromethyl)benzylidenemalonate 
• 863870-43-3 2-(2,2-dibromovinyl)-5-(trifluoromethyl)phenylamine 
• 880153-92-4 {(S)-1-[2-(2,2-Dibromo-vinyl)-5-trifluoromethyl-phenylcarbamoyl]-ethyl}-carbamic acid benzyl ester 
• 441787-03-7 diethyl 2-ethoxy-2-(2-nitro-4-(trifluoromethyl)phenyl)ethane-1,1-dicarboxylate 
• 1070901-28-8 (E)-ethyl 4-[(4-bromophenyl)(2-(tert-butylamino)-1-(2-nitro-4-(trifluoromethyl)phenyl)-2-oxoethyl)amino]-4-oxobut-2-enoate 
• 71083-18-6 7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester 
• 1204508-23-5 2-azido-4-(trifluoromethyl)benzaldehyde 
• 1283597-27-2 N-(2-bromobenzyl)-1-(2-nitro-4-(trifluoromethyl)phenyl)methanamine 
• 1283597-28-3 N-(2-bromobenzyl)-N-methyl-1-(2-nitro-4-(trifluoromethyl)phenyl)methanamine 
• 1283597-16-9 2-(((2-bromobenzyl)(methyl)amino)methyl)-5-(trifluoromethyl)aniline 
• 1279722-74-5 C₁₈H₁₄F₃N₃ 

Relevant articles and documents

A O-nitrobenzaldehyde synthetic method of compound

The invention provides a preparation method for an o-nitrobenzaldehyde compound. The method directly taking benzaldehyde compounds as starting raw materials comprises the following steps: firstly, converting a formyl group into an O-methyl oximido; secondly, taking divalent palladium salt as a catalyst, and realizing the carbon-hydrogen bond activation single nitration reaction on an o-position of an oximido under the condition that both an oxidant and a nitration agent exist; finally, removing the O-methyl oximido by using strong organic acid to obtain the o-nitrobenzaldehyde compound. The nitration method provided by the invention has the advantage of specificity in the o-position of a nitration position, the reaction process is safe and environment-friendly, the substrate is excellent in adaptability, and various substituents can realize o-position nitration; various benzaldehyde is directly taken as raw materials, so that the reaction steps are simple, and the synthesizing method is a novel route for synthesizing various o-nitrobenzaldehyde compounds containing substituents.

A highly selective tandem cross-coupling of gem-dihaloolefins for a modular, efficient synthesis of highly functionalized indoles

(Chemical Equation Presented) A highly efficient method of indole synthesis using gem-dihalovinylaniline substrates and an organoboron reagent was developed via a Pd-catalyzed tandem intramolecular amination and an intermolecular Suzuki coupling. Aryl, alkenyl, and alkyl boron reagents are all successfully employed, making for a versatile modular approach. The reaction tolerates a variety of substitution patterns on the aniline leading to indoles with group at C2-C7. The orthogonal approach of the sequential copper- and palladium-mediated synthesis of 1,2-diarylindoles exploited the wide availability of diverse organoboron reagents.

4 Benzoyl isoxazole derivatives

4-Benzoyl isoxazole derivatives of the formula I: wherein:, R represents alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted cycloalkyl, -CO2R3,-COR5,cyano,nitro, -CONR31R4 or a halogen atom;, R1 represents :-, hydrogen , alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl or optionally substituted cycloalkyl, R2 represents :-, halogen, R5, -SR5, -SOR5, -SO2R5, -SO2NR31R4,-CO2R3, -COR5, -CONR31R4, -CSNR31R4, -OR5, a nitro group, a cyano group, a group -O(CH2)q-OR5 or alkyl substituted by OR5;, R3, R31 and R4, which may be the same or different, each represents:-, hydrogen, alkyl or haloalkyl;, R5 represents alkyl or haloalkyl;, n represents an integer from 1 to 5; and, q represents an integer from 1 to 3;, and agriculturally acceptable salts thereof and their use as herbicides is described.