1094677-96-9

Basic information

• Product Name: 6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(N-[benzyloxycarbonyl]sulfamoyl)aminodeoxyadenosine
• CAS NO: 1094677-96-9
• Molecular Weight: 619.656
• Mol File: 1094677-96-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(N-[benzyloxycarbonyl]sulfamoyl)aminodeoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(N-[benzyloxycarbonyl]sulfamoyl)aminodeoxyadenosine(1094677-96-9)
• EPA Substance Registry System: 6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(N-[benzyloxycarbonyl]sulfamoyl)aminodeoxyadenosine(1094677-96-9)

Safety Data

• Hazardous Substances Data: 1094677-96-9(Hazardous Substances Data)

Upstream product

• 873556-45-7 tert-butyl 9-(((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate 
• 1037211-09-8 N-benzyloxycarbonyl-N'-(4-[dimethylazaniumylidene]-1,4-dihydropyridin-1-ylsulfonyl)azanide 

Relevant articles and documents

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

Menaquinone (vitamin K2) is an essential component of the electron transfer chain in many pathogens, including Mycobacterium tuberculosis and Staphylococcus aureus, and menaquinone biosynthesis is a potential target for antibiotic drug discovery. We report herein a series of mechanism-based inhibitors of MenE, an acyl-CoA synthetase that catalyzes adenylation and thioesterification of o-succinylbenzoic acid (OSB) during menaquinone biosynthesis. The most potent compound inhibits MenE with an IC50 value of 5.7 μM.