1095792-53-2Relevant articles and documents
Preparation method of 2, 4-disubstituted thiazole compound
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Paragraph 0034; 0041-0044; 0081-0084, (2020/11/23)
The invention discloses a preparation method of a 2, 4-disubstituted thiazole compound. The method comprises the following steps: carrying out heating reflux reaction on substituted carboxylic acid inthionyl chloride to obtain yellow transparent liquid, and adding dichloromethane to dilute for later use; in an ice bath, slowly dropwise adding the substituted acyl chloride solution into ammonia water while stirring, stirring at room temperature to separate out a white solid, and after the reaction is finished, carrying out suction filtration, washing and drying to obtain substituted amide; carrying out reflux on substituted amide and Lawesson in tetrahydrofuran, carrying out rotary evaporation to remove the solvent after the reaction is finished, and carrying out column purification on thecrude product to obtain substituted sulfamide. The preparation method comprises the following steps: putting substituted sulfamide, ethanol, triethylamine and an alpha-bromocarbonyl compound into a pressure reaction tank, putting the pressure reaction tank into an annular focusing single-mode microwave synthesizer for irradiation, and cooling with compressed air to obtain a target compound. Basedon microwave synthesis, the invention has the advantages of short reaction time, high yield, high heating speed, environment friendliness and the like, and provides a microwave synthesis method of a2, 4-disubstituted thiazole compound.
One-step three-component and solvent-free synthesis of thiazoles from tertiary thioamides
Zali-Boeini, Hassan,Mansouri, Seyed Gholamhossein
, p. 1571 - 1577 (2016/07/27)
Abstract: A novel one-pot three-component reaction has been developed for construction of thiazole derivatives under solvent-free conditions. Hence, tertiary thioamides, α-haloketones, and NH4OAc were grinded together and allowed to react thermally at 110?°C and/or under microwave irradiation to produce the corresponding thiazole derivatives in very good yields. Graphical Abstract: [Figure not available: see fulltext.]