1095825-44-7

Basic information

• Product Name: C₁₂H₁₀ClF₃N₄OS
• CAS NO: 1095825-44-7
• Molecular Weight: 350.752
• Mol File: 1095825-44-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₀ClF₃N₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₀ClF₃N₄OS(1095825-44-7)
• EPA Substance Registry System: C₁₂H₁₀ClF₃N₄OS(1095825-44-7)

Safety Data

• Hazardous Substances Data: 1095825-44-7(Hazardous Substances Data)

Upstream product

• 1095825-46-9 2-acetyl-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide 
• 1095823-56-5 2-(1-aminoethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND

The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale. Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof. wherein each symbol is as defined in the specification.

COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.