109635-64-5 Usage
Description
Nonaethylenel di(p-toluenesulfonate), also known as Tos-PEG10-Tos, is a PEG (polyethylene glycol) linker containing two tosyl groups. It is characterized by its hydrophilic PEG spacer, which enhances solubility in aqueous media, and the tosyl group, which acts as an excellent leaving group for nucleophilic substitution reactions. This unique structure makes it a versatile compound with potential applications in various fields.
Uses
Used in Chemical Synthesis:
Nonaethylenel di(p-toluenesulfonate) is used as a reactant for the synthesis of crown ethers. The application reason is that the tosyl group in the compound serves as a good leaving group, facilitating the formation of crown ethers through nucleophilic substitution reactions.
Used in the Pharmaceutical Industry:
In the pharmaceutical industry, Nonaethylenel di(p-toluenesulfonate) is used as a building block for the development of novel drug delivery systems. The hydrophilic PEG spacer increases the solubility of the compound in aqueous media, making it suitable for the design of water-soluble drug carriers and improving the bioavailability of various therapeutic agents.
Used in the Chemical Research Industry:
Nonaethylenel di(p-toluenesulfonate) is utilized as a research tool in the chemical research industry. Its unique structure allows scientists to study the properties and reactivity of PEG linkers and tosyl groups, leading to the development of new synthetic methods and applications in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 109635-64-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,6,3 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 109635-64:
(8*1)+(7*0)+(6*9)+(5*6)+(4*3)+(3*5)+(2*6)+(1*4)=135
135 % 10 = 5
So 109635-64-5 is a valid CAS Registry Number.
109635-64-5Relevant articles and documents
Preparation and crystallinity of a large unsubstituted crown ether, cyclic heptacosa(oxyethylene) (cyclo-E27, 81-crown-27), studied by Raman spectroscopy, X-ray scattering and differential scanning calorimetry
Yang, Zhuo,Yu, Ga-Er,Cooke, Jennifer,Ali-Adib, Ziad,Viras, Kyriakos,Matsuura, Hiroatsu,Ryan, Anthony J.,Booth, Colin
, p. 3173 - 3182 (2007/10/03)
Cyclic heptacosa(oxyethyelene) (cyclo-E27, 81-crown-27) was prepared from linear α-hydro, ω-hydroxy-heptacosa(oxyethylene) by reaction with tosyl chloride under alkaline conditions, purified by preparative-scale gel permeation chromatography, and studied by laser-Raman spectroscopy, wide-angle and small-angle X-ray scattering, and differential scanning calorimetry. Comparison was made with the properties of linear oligo(oxyethylene) dimethyl ethers (including C1E27C1). The sub-cell of the crystalline cyclic oligomer was the same as that of its linear counterparts, i.e. the same as that of high-molar-mass poly(oxyethylene). However, the cyclic oligomer crystallised as a twice-folded ring, as confirmed by its long spacing and the frequency of its single-node longitudinal acoustic mode (LAM-1). Enthalpies of fusion and melting temperatures were analysed to provide estimates of the enthalpy and entropy of formation of a fold in an oligo(oxyethylene) layer crystal.
