109671-52-5

Basic information

• Product Name: 5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE
• Synonyms: 5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE;2-amino-4-chloro-6-methylphenylamine;(2-amino-4-chloro-6-methylphenyl)amine(SALTDATA: HCl);1,2-BenzenediaMine, 5-chloro-3-Methyl-;5-chloro-3-methylbenzene-1,2-diamine
• CAS NO: 109671-52-5
• Molecular Formula: C₇H₉ClN₂
• Molecular Weight: 156.61
• Product Categories: pharmacetical
• Mol File: 109671-52-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 309.8°Cat760mmHg
• Flash Point: 141.1°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 0.000626mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE(109671-52-5)
• EPA Substance Registry System: 5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE(109671-52-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-36
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 109671-52-5(Hazardous Substances Data)

Usage

General Description

5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE is a chemical compound with the molecular formula C7H9ClN2. It is a derivative of phenylenediamine and is commonly used in hair dye products. 5-CHLORO-3-METHYL-1,2-PHENYLENEDIAMINE is a dark solid and is insoluble in water. It is known to have skin and eye irritant properties and can cause allergic reactions in some individuals. Due to its potential health risks, it should be handled and used with care and following safety guidelines.

InChI:InChI=1/C7H9ClN2/c1-4-2-5(8)3-6(9)7(4)10/h2-3H,9-10H2,1H3

Upstream product

• 62790-50-5 4-chloro-2-methyl-6-nitrophenylamine 
• 570-24-1 2-Methyl-6-nitroaniline 

Downstream Products

• 180508-09-2 6-chloro-4-methylbenzimidazole 
• 532934-94-4 6-chloro-8-methylquinoxaline 
• 180569-27-1 6-chlorobenzimidazole-4-carboxylic acid 
• 109671-53-6 7-methyl-5-methylamino-4-nitro-2,1,3-benzoselenadiazole 
• 848848-15-7 {2-(6-Chloro-4-methyl-1H-benzoimidazol-2-yl)-5-[3-(1-methyl-piperidin-4-yl)-propoxy]-benzyl}-dimethyl-amine 
• 848848-24-8 4-{3-[4-(6-chloro-4-methyl-1H-benzoimidazol-2-yl)-3-methyl-phenoxy]-propyl}-5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester 
• 848848-29-3 4-{3-[4-(6-chloro-4-methyl-1H-benzoimidazol-2-yl)-3-methyl-phenoxy]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 1035389-38-8 tert-butyl 4-(2-amino-5-chloro-3-methylphenylcarbamoyl)-4-(tert-butoxycarbonylamino)piperidine-1-carboxylate e 

Relevant articles and documents

Broad spectrum chemistry as practised by Novartis process research

Three actual examples from the current product palette within Novartis Process Research will demonstrate the some of the variety and challenges encountered in modern chemical development.

Synthesis of the potent mutagen 3,5,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.

The mutagenic title compound (5,8-DiMeIQx) was synthesized by two different routes: from 2-methyl-4,6-dinitroaniline; and from 4-chloro-2-methyl-6-nitroaniline. The latter and more convenient route involved 2,1,3-benzoselenadiazole intermediates.