1097034-64-4Relevant articles and documents
Selective synthetic routes to sterically hindered unsymmetrical diaryl ketones via arylstannanes
Lo Fiego, Marcos J.,Silbestri, Gustavo F.,Chopa, Alicia B.,Lockhart, Maria T.
body text, p. 1707 - 1714 (2011/05/17)
Bulky arylstannanes and bulky aroyl chlorides are good reaction partners for the synthesis of two-, three-, and even four-ortho-substituted benzophenones, in good to excellent isolated yields (47-91%). Three simple and direct routes, with differential advantages, are proposed: (i) a catalyst-free protocol, in o-dichlorobenzene (ODCB) at 180 °C; (ii) a room temperature protocol, using AlCl3 (0.5 equiv), in dichloromethane (DCM); and (iii) a solvent-free, indium-promoted procedure. A radical mechanism is proposed for the indium-mediated reactions.2011 American Chemical Society.
