109721-08-6 Usage
Description
(S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester, also known as dimethyl methylsilanediol, is a chemical compound with the molecular formula C9H20O5Si. It is an ester derivative of pentanedioic acid and is characterized by its ability to act as a protective group for carboxylic acids during chemical reactions. This versatile compound is widely utilized in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of silicone polymers.
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
(S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is used as a protective group for carboxylic acids in the pharmaceutical and agrochemical industries. Its protective role ensures the selective functionalization of specific sites in complex molecules, facilitating the synthesis of a wide range of therapeutic and pesticidal compounds.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is used as a reagent for the preparation of various compounds. Its unique properties allow for the creation of a diverse array of molecules for medicinal and industrial applications, contributing to the development of new products and technologies.
Used in Silicone Polymer Production:
(S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is a key component in the production of silicone polymers. These polymers are widely used across multiple industries, including automotive, construction, and electronics, due to their exceptional properties such as heat resistance, chemical stability, and electrical insulating capabilities.
Used in the Automotive Industry:
In the automotive industry, (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is used in the production of silicone polymers for applications such as seals, gaskets, and engine components. These polymers provide enhanced performance and durability in the demanding conditions of automotive systems.
Used in the Construction Industry:
(S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is utilized in the construction industry for the creation of silicone-based materials, such as sealants, adhesives, and coatings. These materials offer superior weather resistance, flexibility, and longevity, making them ideal for use in building and infrastructure projects.
Used in the Electronics Industry:
In the electronics industry, (S)-3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is employed in the production of silicone polymers for applications like electrical insulation, heat dissipation, and protective coatings. These materials are crucial for the reliable and efficient functioning of electronic devices and systems.
Check Digit Verification of cas no
The CAS Registry Mumber 109721-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,7,2 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 109721-08:
(8*1)+(7*0)+(6*9)+(5*7)+(4*2)+(3*1)+(2*0)+(1*8)=116
116 % 10 = 6
So 109721-08-6 is a valid CAS Registry Number.
109721-08-6Relevant articles and documents
Engineering of the Conformational Dynamics of Lipase to Increase Enantioselectivity
Yang, Bin,Wang, Hongjiang,Song, Wei,Chen, Xiulai,Liu, Jia,Luo, Qiuling,Liu, Liming
, p. 7593 - 7599 (2017)
In order to increase the R-enantioselectivity of Candida antarctica lipase B (CALB) toward (R)-3-t-butyl-dimethyl-silyloxy glutaric acid methyl monoester at 30 °C, we engineered CALB conformational dynamics. Based on structural analysis and molecular dynamics simulations, two key residues (D223 and A281) were identified, and three mutants (D223V, A281S, and D223V/A281S) were designed to decrease the conformational dynamics of the pocket and channel. Computational and experimental evaluations were performed for all mutants, with the D223V/A281S mutant exhibiting high R-enantioselectivity (>99.00%; increased from 8.00%) and high space-time yield (107.54 g L-1 d-1 a 5.70-fold increase).
Synthesis of Novel HMG-CoA Reductase Inhibitors, I Naphthalene Analogs of Mevinolin
Novak, Lajos,Rohaly, Janos,Poppe, Laszlo,Hornyanszky, Gabor,Kolonits, Pal,et al.
, p. 145 - 158 (2007/10/02)
The title compounds 2 and their corresponding (6S) epimers 18 are prepared in several steps by starting with chiral formyl ester 5, and α-tetralones 10: (1) coupling reaction with the ylide generated from 11 to yield unsaturated ester 13, (2) reduction to the corresponding alcohol 14, (3) addition of the Grignard reagent derived from 14 to formyl ester 5 to afford the hydroxy esters 16 and 17, and (4) lactonization.This procedure is also used to synthesize the β-naphthyl analogs 29 and 30.Some results obtained from HMG-CoA reductase inhibitor screening are also reported. Key Words: HMG-CoA reductase inhibitors / Naphthylacetates / Pig liver esterase / Glutarate, 3-hydroxy / Lactones
