109765-52-8Relevant articles and documents
Efficient synthesis of key intermediate toward liphagal synthesis
Deore, Vijaykumar,Lohar, Manoj Kumar,Mundada, Ramswaroop,Roychowdhury, Abhijit,Vishwakarma, Ram,Kumar, Sanjay
, p. 177 - 183 (2011)
Liphagal (A) is a very potent and selective inhibitor of PI3K (p110) and is under development for an oncolytic drug. We herein report the new and concise synthesis of key intermediates (7, 8), which have been used for liphagal synthesis and will be useful
Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal
Pereira, Alban R.,Strangman, Wendy K.,Marion, Frederic,Feldberg, Larry,Roll, Deborah,Mallon, Robert,Hollander, Irwin,Andersen, Raymond J.
, p. 8523 - 8533 (2011/02/26)
Analogues of the sponge meroterpenoid liphagal (1) have been synthesized and evaluated for inhibition of PI3Kα and PI3Kα as part of a program aimed at developing new isoform-selective PI3K inhibitors. One of the analogues, compound 24, with IC50/sub
Liphagal, a selective inhibitor of PI3 kinase α isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis
Marion, Frederic,Williams, David E.,Patrick, Brian O.,Hollander, Irwin,Mallon, Robert,Kim, Steven C.,Roll, Deborah M.,Feldberg, Larry,Van Soest, Rob,Andersen, Raymond J.
, p. 321 - 324 (2007/10/03)
Liphagal (1), a selective inhibitor of PI3K α, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the
