1097920-69-8

Basic information

• Product Name: 4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate
• Synonyms: 4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate
• CAS NO: 1097920-69-8
• Molecular Weight: 390.48
• Mol File: 1097920-69-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate(1097920-69-8)
• EPA Substance Registry System: 4-benzyl 9-tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4,9-dicarboxylate(1097920-69-8)

Safety Data

• Hazardous Substances Data: 1097920-69-8(Hazardous Substances Data)

Upstream product

• 930785-40-3 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 930785-40-3 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester 
• 1402232-57-8 benzyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate hydrochloride 

Relevant articles and documents

BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.