109793-65-9

Basic information

• Product Name: [1-Phenyl-eth-(Z)-ylidene]-pyrrolidin-1-yl-amine
• Synonyms: [1-Phenyl-eth-(Z)-ylidene]-pyrrolidin-1-yl-amine
• CAS NO: 109793-65-9
• Molecular Weight: 188.272
• Mol File: 109793-65-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-Phenyl-eth-(Z)-ylidene]-pyrrolidin-1-yl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [1-Phenyl-eth-(Z)-ylidene]-pyrrolidin-1-yl-amine(109793-65-9)
• EPA Substance Registry System: [1-Phenyl-eth-(Z)-ylidene]-pyrrolidin-1-yl-amine(109793-65-9)

Safety Data

• Hazardous Substances Data: 109793-65-9(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 16596-41-1 N-aminopyrrolidine 

Relevant articles and documents

Inhibiteurs mixtes des voies de la cyclooxygenase et des lipoxygenases: synthese et activite de derives hydrazoniques

Dual inhibitors of the cyclooxygenase and lipoxygenase pathways: synthesis and activity of hydrazone derivatives.Non-steroidal anti-inflammatory drugs (NSAIDs) act by preventing prostaglandin production.In recent years, research on non-steroid dual inhibitors of prostaglandin and leukotriene biosyntheses has been developed.These compounds should represent a new class of anti-inflammatory drugs, with a wider spectrum of activity than classical NSAIDs.The present paper reports the synthesis of hydrazone derivatives.The effect of various substitutions is studied on platelet cyclooxygenase (i.e. prostaglandin synthesis) and on leukocyte 5-lipoxygenase (i.e. leukotriene synthesis).Among the 50 tested compounds, 2 hydrazone derivatives were selected for their significant dual inhibitory potency: 2-acetylthiophene-2-thiazolylhydrazone 5g, and N-phenyl benzimidrazone 6c.Keywords - non-steroidal anti-inflammatory drugs / hydrazones / dual inhibitor / cyclooxygenase / lipoxygenase